You can leave it running over night just make sure to keep the lot sizes the way they are on the .set files
\
He recommends to start at 14hours in the .set file to hit the target profit faster.
\
You can leave the ea running during any kind of news (unless the prop firm rules says you cant) but if you are a beginner he recommends to not use the ea after 5-10 minutes after news already dropped, although he says that he likes news days.\
\
After setting up the ea with the .set files he gives you, all you have to do after that is change the lucky number to any number you want and you can leave it running on its own until you reach your profit target.